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Elzira Iskakova

Candidate of Medical Science

Education:

1991–1997: Student, Semipalatinsk State Medical Academy, Physician (General Medicine), Kazakhstan

1996–1997: Subintern, Semipalatinsk State Medical Academy, Specialty: Obstetrics and Gynecology

1999–2000: Internship, Aktobe State Medical Academy, Specialty: Obstetrics and Gynecology

2003–2005: Clinical Residency, Kazakh National Medical University, Specialty: Obstetrics and Gynecology

2006–2009: Postgraduate Student, Kazakh National Medical University named after S.D. Asfendiyarov, Specialty: Pathological Anatomy. Dissertation: Pathomorphological features of genital endometriosis

2012–2013: Internship, University of Reading, UK, Specialty: Molecular and Cellular Biology. Research: Effect of aluminum compounds on migration and invasion of human breast cancer MCF-7 cells and normal breast epithelial MCF-10A cells in culture

Advanced Training:

2023: Advanced Training, Selected Issues in Pathomorphological Diagnostics in Oncology, 120 hours

2020: Advanced Training, Selected Issues in Pathomorphological Diagnostics in Oncology, 216 hours

2016: Advanced Training, Fundamentals of Immunohistochemical Research in Clinical Practice

2014: Advanced Training, Medical Education for Healthcare Organizations and Research Institutions

2014: Advanced Training, Morphological and Clinical Aspects of Congenital Malformations in Early Childhood

2014: Seminar, Renal Pathology, KazNMU, Almaty

2013: Seminar, Medical Education, Salzburg, Austria

2013: Seminar, Immunogenetic Aspects of Cancer Screening, KazNMU, Almaty

2010: Advanced Training, Scientific Research Management, Institute for Healthcare Development, Astana

2009: Seminar, Pathology, Salzburg, Austria

2008: Seminar, Modern Approaches in Diagnosis and Treatment of Breast Cancer, Almaty

2008: Course, Fundamentals of Immunohistochemical and Molecular Biological Tumor Diagnostics, Herzen Oncology Institute, Moscow, Russia

2006: Primary Specialization, Clinical Morphology, Almaty

Professional Experience:

2000–2002: Obstetrician-Gynecologist, Polyclinic No.6, Kyzylorda

2002–2003: Obstetrician-Gynecologist, Perinatal Center, Kyzylorda

2004–2007: Pathologist, Emergency Medical Hospital, Almaty

2006–2014: Assistant, Department of Pathological Anatomy, KazNMU named after S.D. Asfendiyarov, Almaty

2007–2009: Pathologist, City Cardiology Center, Almaty

2010–2011: Head of Scientific and Clinical Work Department, KazNMU named after S.D. Asfendiyarov

2014–2016: Acting Associate Professor, Module of Pathological Anatomy, KazNMU named after S.D. Asfendiyarov, Almaty

2016–2019: Pathologist, Department No.3, City Pathology Bureau, Almaty

2019–present: Pathologist, Morphological Research Center, Kazakh Research Institute of Oncology and Radiology

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Nariman Mukhametgaliev

Candidate of Medical Sciences

Education:

1989 – Graduated with honors from the Faculty of General Medicine, Almaty State Medical Institute.

International Trainings:

2005: Specialization, Immunology Laboratory, National Center for Pediatrics and Pediatric Surgery, Immunophenotyping of leukemias and lymphomas using flow cytometry

2006: Histological and cytological tumor diagnostics, Department of Molecular Pathology, Nagasaki University, Japan

2013: Bone marrow trephine biopsy, determination of CD34 stem cell concentration by flow cytometry, Clinical and Laboratory Diagnostics of Hematologic Malignancies, Federal State Budgetary Educational Institution of Higher Professional Education Pavlov First Saint Petersburg State Medical University, Russia

2014: Soft tissue sarcomas, Theoretical Foundations and Clinical Cases in Oncology, Gustave Roussy Institute, Paris, France

Mukhametkali Akhmetkaliyev

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Mukhametkali Akhmetkaliyev

Candidate of Medical Sciences

Education:

Almaty State Medical Institute, 1992, Kazakhstan.

Clinical guidelines, monographs, textbooks:

Morphofunctional Changes of the Azygos Vein and Their Significance in the Diagnosis of Portal Hypertension. Textbook. Almaty, 2003, illustrated, 53 p., co-author G.N. Andreev.

Morphological Changes of the Azygos Vein and Its Relationship with the Esophageal Veins in Portal Hypertension. Monograph, Veliky Novgorod, 2005, 102 p., co-authors: G.N. Andreev, N.I. Kolycheva, S.T. Turmakhanov, L.N. Akhmetkaliyeva.

Practical Guide for Pathologists on the Examination of Autopsy and Biopsy-Surgical Material. Textbook. Almaty, 2006, 50 p.

Morphological Examination in Pulmonary and Extrapulmonary Tuberculosis. Methodological guidelines, Almaty, 2009, 57 p., co-author Sh.Sh. Ismailov.

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Aigul Aubakirova

Candidate of Biological Sciences

Education:

Al-Farabi Kazakh National Medical University (KazNMU), 2001, Kazakhstan

Higher School of Public Health, 2015, Kazakhstan

h-index: 2, Scopus author ID: 55249544400

Research Areas: clinical-laboratory, immunological, and molecular-genetic studies

Participation in Scientific Projects: 2017–2019: PCF with MUH and KazNMU named after S.D. Asfendiyarov – Senior Researcher

Patents:

Method for treating generalized forms of malignant lymphomas. Pre-patent №16145, 2004/0256.1, 27.02.2004

Method for stimulating interleukin-2 production during lung cancer chemotherapy. Pre-patent №17717, 2005/0282.1, 01.03.2005

Method for stimulating tumor necrosis factor-alpha production during lung cancer chemotherapy. Pre-patent №17715, 2005/0280.1, 01.03.2005

Method for stimulating interferon-γ production during lung cancer chemotherapy. Pre-patent №17716, 2005/0281.1, 01.03.2005

Method for stimulating immunity in patients with lung cancer. Innovative patent №21539, 2007/1111.1, 28.08.2007

Method for stimulating immunity in patients with laryngeal cancer. Innovative patent №21541, 2007/0962.1, 11.07.2007

Innovative patent №22026, 2008/1381.1, 15.12.2008

Method for stimulating immunity in patients with lung cancer. Innovative patent №2007/1111.1, 01.03.2005

Method for predicting clinical course of advanced ovarian cancer. Innovative patent №24583, published 15.09.2011

Method for predicting clinical course of advanced ovarian cancer. Innovative patent №24582, published 15.09.2011

Method for ultrasound diagnosis of experimental nonspecific chronic orchiepididymitis. Innovative patent №27590, published 15.11.2013

Method for modeling experimental chronic orchiepididymitis. Innovative patent №27590, published 15.08.2013

Method for modeling experimental acute orchiepididymitis. Innovative patent №26852, published 15.05.2013

Method for immunological prediction of male fertility disorders. Patent №031701, published 14.07.2015

Method for immunological prediction of male fertility disorders. Patent №031700, published 14.07.2015

Method for ultrasound diagnosis of erectile dysfunction. Innovative patent №30739, published 25.12.2015

Method for ultrasound diagnosis of experimental nonspecific chronic orchiepididymitis. Eurasian patent №023491, 30.06.2016

Method for assessing sperm DNA chromatin. Utility model patent №2017/0814.2, 30.05.2018 №840 19–25. Certificates of entry into the state register of copyright-protected objects (2020–2024) – covering methodological recommendations and literary works on emergency surgery during COVID-19, kidney transplantation, atrial fibrillation, and CYP3A5 gene polymorphism in transplant patients.

Clinical Guidelines, Monographs, Textbooks:

Laboratory studies in andrological diseases, Monograph, 2012, 80 p. ISBN 978-601-7375-14-0

Combined treatment of lung cancer, Monograph, 2017, 177 p. ISBN 978-601-305-105-5

Autocytokine therapy in surgical treatment of lung cancer, Methodological recommendations, 2008, 21 p.

Methods for modeling nonspecific infectious orchiepididymitis in experiments, Methodological recommendations, 2012, 14 p. ISBN 978-601-7375-00-3

Laboratory diagnostics in uro-andrological diseases, Methodological recommendations, 2012, 28 p. ISBN 978-601-7375-06-5

Staff performance control rating system, Methodological recommendations, 2012, 32 p. ISBN 978-601-7375-04-1

Extraction and purification of nucleic acids for methylation status determination in patients with benign prostatic hyperplasia and prostate cancer, 2013, 17 p.

Methodological recommendations for primary prevention of tobacco use and reproductive health protection, 2015, 17 p.

Primary and secondary prevention of male reproductive system disorders at primary health care level, 2015, 33 p.

Algorithm for laboratory diagnosis of idiopathic male infertility, 2016, 23 p.

Analytical reviews of the state of urological services in Kazakhstan, 2011–2016, 121–150 p.

Map of major urological diseases, 2016, 41 p.

Emergency surgical care during COVID-19 pandemic, 2020, 41 p., ISBN 978-601-7446-14-7

Kidney retrieval from deceased donors, 2020, 22 p.

Keyword of research field: clinical-laboratory, immunological, molecular-genetic studies

Recent Publications in KOKSON Journals in the last 5 years:

Aubakirova A.T., et al. Analysis of quality of laboratory studies performed in 2018–2019 in the clinical and diagnostic laboratory of A.N. Syzganov’s NSCS. Vestnik Khirurgii Kazakhstana, 2020;3(64):10-13.

Baimakhanov B.B., Medeubekov U.Sh., Sagatov I.E., Aubakirova A.T. Fighting for people’s lives (75th anniversary of A.N. Syzganov). Vestnik Khirurgii Kazakhstana, 2020;4(65):5-9.

Medeubekov U.Sh., Baimakhanov B.B., Sagatov I.E., Aubakirova A.T. History of the development of the National Scientific Center of Surgery named after A.N. Syzganov (75th anniversary). Reports of NAS RK, 2020;6:124-129.

Aubakirova A.T., et al. Prognostic clinical significance of myeloid suppressor cells and T regulatory cells in sepsis (Review). Vestnik Khirurgii Kazakhstana, 2021;1(66):44-48.
 5–14. [Additional publications on microbiological monitoring, COVID-19 surveys, atrial fibrillation, PCR diagnostics, oncology markers, and transplantation genetics, 2021–2025, including Scopus-indexed articles.]

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Madina Orazgaliyeva

Candidate of Biological Sciences

Education (name, year of graduation, country):

Faculty of Medicine and Biology, Karaganda State Medical Academy, 1999, Kazakhstan

Hirsch index – 2, ResearcherID: D-79885, ORCID: 0000-0001-8191-2068, Scopus Author ID: 58122889000

SCOPUS profile link: https://www.scopus.com/authid/detail.uri?authorId=58122889000

Research areas: Human genetics (search and analysis of disease-predisposing genes), molecular oncology, hematology

Participation in scientific projects :

AP05131940: Possibilities of determining T lymphocyte markers in early diagnosis and prognosis of lung and breast cancer.

AP05135730: Prognostic value of clinico-genetic and immunohistochemical characteristics of colorectal cancer (CRC).

BR07351754: National program for the implementation of personalized and preventive medicine in the Republic of Kazakhstan.

BR07351782: Identification of genetic defects in natural killer cells in oncological diseases.

AP19676226: Study of genetic markers and environmental factors in phakomatoses and neurogenic tumors.

AP05133385-OT-19: Prognostic stratification of differentiated thyroid cancer based on genetic analysis.

BR11065390: Development and advancement of innovative technologies for early diagnosis and treatment of malignant diseases using modern genomics approaches.

BR24992933: Development and implementation of diagnostic models, treatment technologies, and rehabilitation for oncology patients.

Patents:

Method for early diagnosis of lung cancer (Application No.: 2019/0774.1; Filed: 21.10.2019; Patent No.: 34716; Bulletin No.: 46; Date: 20.11.2020) – co-author

Method for early diagnosis of predisposition to breast cancer in Kazakh ethnic women in Kazakhstan (Application No.: 2020/0680.1; Filed: 06.10.2020; Patent No.: 35376) – co-author

Eurasian patent for early diagnosis of breast cancer in Kazakh women based on DNA methylation of mononuclear fraction in peripheral blood plasma (Application No.: KZ2021/050; Filed: 04.10.2021; Patent No.: 202192529; Issued: 15.11.2022) – co-author

Algorithm for testing BRCA1 and BRCA2 mutations in Kazakh women with epithelial ovarian cancer (Copyright: Scientific Work No. 39423, 05.10.2023) – co-author

Monographs, clinical guidelines, textbooks:

Svyatova G.S., Orazgaliyeva M.G. Analysis of the phenylalanine hydroxylase gene in patients with phenylketonuria in populations of the Republic of Kazakhstan, Almaty, 2008

Keyword of research field: genetics, oncology, biomarkers, mutations

Recent Publications in KOKSON Journals in the last 5 years:

Goncharova T.G., Kaidarova D.R., Kadyrbayeva R.E., Orazgaliyeva M.G., Adilbay D.G., Cheishvili D., Vaisheva F., Szyf M. Development of a method for early diagnosis of lung cancer based on DNA methylation of mononuclear blood cells, Oncology and Radiology of Kazakhstan, 2020, No.3(57), pp. 13-20.

Kadyrbayeva R., Askandirova A., Omarbayeva N., Adylbai D., Goncharova T., Orazgaliyeva M. Epigenetic research in diagnosis and treatment of lung cancer: literature review, Oncology and Radiology of Kazakhstan, 2020, No.3(57), pp. 44-47.

Goncharova T.G., Kaidarova D.R., Omarbayeva N.A., Askandirova A.B., Orazgaliyeva M.G., Adilbay D.G., Cheishvili D., Vaisheva F., Szyf M. Development of a method for early diagnosis of breast cancer based on epigenetic markers, Oncology and Radiology of Kazakhstan, 2020, No.4(58), pp. 29-35.

Ermekova S.A., Orazgaliyeva M.G., Goncharova T.G., Rakhimbekova F., Serik E.S. Mutational damages of p53 and EGFR genes in malignant lung tumors, Oncology and Radiology of Kazakhstan, 2021, No.4(62), pp. 28-34. DOI:10.52532/2521-6414-2021-4-62-28-347

Shatkovskaya O.V., Kaidarova D.R., Orazgaliyeva M.G., Satbayeva E.B., Ossikbayeva S.O., Koishybaeva A.B. Optimization of molecular-genetic diagnostics of advanced non-small cell lung cancer through ROS1 testing in Kazakhstan, Oncology and Radiology of Kazakhstan, 2023, No.2(68), pp. 15-21. DOI: 10.52532/2521-6414-2023-2-68-15-21

Rahimbekova F.K., Orazgaliyeva M.G., Goncharova T.G. Impact of chloride and lead ions in open water sources on cancer incidence in Kyzylorda region, Oncology and Radiology of Kazakhstan, 2023, No.3(69), pp. 11-15

Yermekova S., Orazgaliyeva M., Goncharova T., Rakhimbekova F., Dushimova Z., Vasilieva T. Mutational damages in gastric and colorectal adenocarcinomas, Asian Pacific Journal of Cancer Prevention, 2023, Vol.24(11), pp. 3939-3947. DOI: 10.31557/APJCP.2023.24.11.3939

Amankulov J., Kaidarova D., Zholdybay Z., Zagurovskaya M., Shatkovskaya O., Ainakulova A., Orazgaliyeva M. Natural killer cell activity level in colorectal cancer screening in an average risk population, Archives of Medical Science, 2023, Vol.6. DOI: https://doi.org/10.5114/aoms/142101

Goncharova T.G., Omarbayeva N.A., Kaidarova D.R., Abdrakhmanova A.Zh., Smagulova K.K., Orazgaliyeva M.G., Shatkovskaya O.V., Malysheva L.A., Zkrina A.M., Dushimova Z.D. Impact of gene polymorphisms associated with breast cancer on chemotherapy efficacy, Tumors of the Female Reproductive System, 2024, Vol.20(2), pp.32-47

Kadyrbayeva R., Kaidarova D., Shatkovskaya O., Goncharova T., Orazgaliyeva M. EGFR T790M mutation detection in NSCLC patients resistant to tyrosine kinase inhibitors, Panminerva Medica, 2024. DOI: 10.23736/S0031-0808.24.05172-3

Rahimbekova F., Kaidarova D.R., Orazgaliyeva M., Ryspambetov Z., Buzdin A., Anapiyayev B. Cancer incidence relation to heavy metals in soils of Kyzylorda region of Kazakhstan, Asian Pac J Cancer Prev, 2024, Vol.25(6), pp.1987-1995. DOI: 10.31557/APJCP.2024.25.6.1987

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Saniya Ossikbayeva

PhD

University education (name, year of graduation, country): Al-Farabi Kazakh National University, 2008, Almaty, Kazakhstan

International scientific internships (institution, year, country): None

SCOPUS ID, h-index: Scopus Author ID: 57204570840, h-index: 2

SCOPUS profile link: https://www.scopus.com/authid/detail.uri?authorId=57204570840

Research areas: Biology, oncology, molecular-genetic studies

Participation in scientific projects:

BR24992933: Development and implementation of diagnostic models, treatment technologies, and rehabilitation for oncology patients

Patents:

 Composition based on medicinal plants for normalizing lymphatic system function during aging, Patent No. 7184, 2020

Keyword of research field biology, oncology, molecular-genetic research

Recent Publications in KOKSON Journals in the last 5 years:

Ossikbayeva S.O., Eszhan B.G. Effect of natural polyphenols on Du145 prostate cancer cell cycle, Oncology and Radiology of Kazakhstan, 2020, No.4(58), pp. 44-46.

Demchenko G.A., Tuleukhanov S.T., Abdreshov S.N., Kaleshov A.M., Ossikbayeva S.O., Nurmukhanova B.A., Zhakina K.N. Cellular, biochemical, immunological composition, physical and chemical, rheological parameters of lymph and blood, volume of interstitial fluid, diuresis in young, mature, and old animals, Series of Biological and Medical, 2020, No.3, pp.22-28.

Kaidarova D.R., Dushimova Z.D., Orazgaliyeva M.G., Shatkovskaya O.V., Aliyeva S.T., Ossikbayeva S.O. Molecular-genetic testing of V600 BRAF gene mutations in melanoma patients in Kazakhstan, Oncology and Radiology of Kazakhstan, 2021, No.1(59), pp.20-24.

Eszhan B.G., Ossikbayeva S.O. Mechanism of action of Danazol on oxidative phosphorylation in Mcf10A breast cells, Oncology and Radiology of Kazakhstan, 2021, No.2(60), pp.32-35.

Ishkinin Y.I., Raimbekov R.B., Datbayev K.D., Goncharova A.A., Akhunova R.U., Omarova A.K., Ossikbayeva S.O., Khozhamkul F.A., Omirzaq M.S., Seitov O.K., Khudaibergenov Zh.T., Omarbayeva N.A. Accelerated high-tech radiotherapy during the COVID-19 pandemic, Oncology and Radiology of Kazakhstan, 2023, No.1(67), pp.10-13.

Shatkovskaya O.V., Kaidarova D.R., Orazgaliyeva M.G., Satbayeva E.B., Ossikbayeva S.O., Koishybaeva A.B. Optimization of molecular-genetic diagnostics of patients with advanced non-small cell lung cancer via ROS1 testing in Kazakhstan, Oncology and Radiology of Kazakhstan, 2023, No.2(68), pp.15-21. DOI: 10.52532/2521-6414-2023-2-68-15-21

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Ramil Abdrakhmanov

Head of the Center for Chemotherapy of Tumors, Chairman of the Chemotherapy Council at JSC “KazIOR”

Candidate of Medical Sciences

Medical Oncologist, Chemotherapist of the Highest Qualification Category

Member of the European Society for Medical Oncology (ESMO) and the International Society for Pharmacoeconomics and Outcomes Research (ISPOR), author of scientific publications, recipient of state awards.

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Aliya Abdrakhmanova

Doctor of Medical Sciences, Professor, Oncological Breast Surgeon, Head of the Breast Tumor Center, JSC “KazIOR”

Education:

Alma-Ata State Medical Institute – General Medicine, 1990, Almaty, Kazakhstan

Non-state educational establishment “KRMU” – Breast and Female Reproductive System Tumors, 2014, Almaty, Kazakhstan

Postgraduate Medical Academy – Retraining in Plastic Surgery, 2020, Almaty, Kazakhstan

Kazakh Scientific Center of Dermatology and Infectious Diseases – Oncology: Teaching Methodology in Healthcare, 2022, Almaty, Kazakhstan

Specialization and Advanced Training:

Internship in Turkey (Izmir), 1990–1993

Karaganda Medical University – Advanced training in Oncology, course: “Current Issues in Diagnosis and Treatment of Malignant Tumors,” 2009, Karaganda, Kazakhstan

Karaganda Medical University – Advanced training in Oncology, course: “Current Problems in Mammology,” 2010, Karaganda, Kazakhstan

JSC “KazIOR” – Advanced training in Oncology, course: “Early Diagnosis, Treatment, and Prevention of Breast Tumors,” 2012, Almaty, Kazakhstan

JSC “KazIOR” – Advanced training in Oncology (Mammology, Adult), course: “Chemotargeted and Hormone Therapy of Malignant Tumors,” 2018, Almaty, Kazakhstan

Kazakh Medical University of Continuing Education – Advanced training in Oncology (Chemotherapy, Mammology, Adult), course: “Rehabilitation and Supportive Therapy of Cancer Patients,” 2018, Almaty, Kazakhstan

Postgraduate Medical Academy – Advanced training in General Surgery, course: “Endovideo Surgical Interventions in Abdominal Surgery,” 2019, Almaty, Kazakhstan

JSC “KazIOR” – Advanced training in Oncology (Mammology, Adult), course: “Breast Oncosurgery,” 2019, Almaty, Kazakhstan

Advanced training at Institut Curie, France, including laboratory training in Genetics, 2023

Work Experience: оver 35 years of professional experience in oncology

Dissertations:

Candidate of Medical Sciences: “Intratumoral Radiosensitization in the Combined Therapy of Locally Advanced Breast Cancer,” defended in 1996 at KazIOR

Doctor of Medical Sciences: “Clinical and Epidemiological Aspects of Breast Cancer in Kazakhstan,” defended in 2000 at KazIOR

Research Interests:

Breast cancer

Genetic predisposition

Implementation of preoperative and intraoperative navigational localizers

Fluorescent lymphography methods

Comprehensive breast cancer treatment programs

Additional Information:

Member of international professional associations: ASCO (American Society of Clinical Oncology), ESMO (European Society for Medical Oncology)

Active participation in national and international oncology and mammology conferences, with presentations and publications

Experience in mentoring and supervising PhD students and residents in oncology and mammology

Participation in scientific and technical programs and grant projects aimed at developing personalized medicine and improving breast cancer treatment methods

Teaching activity at the Department of Oncology, D. Asfendiyarov Kazakh National Medical University; involved in training interns and residents in the specialty

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Asem Toguzbaeva

Oncological Breast Surgeon, JSC “KazIOR”; Master, PhD

Education:

• 2001–2008: Tashkent Medical Academy, Bachelor’s degree in General Medicine, Tashkent, Uzbekistan
• 2009–2012: Tashkent Medical Academy, Master’s degree in General Oncology, Tashkent, Uzbekistan
• 2016–2019: S.D. Asfendiyarov Kazakh National Medical University, PhD in Public Health, Almaty, Kazakhstan.

Specialization and Advanced Training:

• 2012: Radiation Therapy, Almaty State Institute of Advanced Medical Studies, Almaty, Kazakhstan
• 2019: General Surgery (thoracic, abdominal, transplantology, colorectal surgery, oncological surgery, ultrasound diagnostics, endoscopy), Postgraduate Medical Academy, Almaty, Kazakhstan
• 2020: Plastic Surgery, 1080 hours, Postgraduate Medical Academy, Almaty, Kazakhstan
• 2014: II International School of Mammoplasty, full lecture course and demonstrative surgeries, Blokhin Branch of the Republican Clinical Oncological Dispensary, Kazan, Russia
• 2019: 5th St. Petersburg International Oncological Forum “White Nights”, St. Petersburg, Russia
• 2024: Specialized training programs in oncoplastic breast surgery and reconstructive surgery, Stavropol Regional Clinical Oncological Dispensary, Stavropol, Russia
• 2025: Advanced training course “Live Surgery Master Class”, Tashkent, Uzbekistan
• Plastic surgery internships:
  • European Institute of Oncology, Milan, Italy, 2018 (3 months)
  • Republic of Tatarstan, Kazan, Russia, December 2024
  • Armenia, Yerevan, June 2024

Work Experience: over 17 years of professional experience in oncology

Dissertation:

• PhD in Public Health, defended on September 19, 2025, on “Medical and Organizational Foundations for Reducing the Burden of Breast Cancer and Improving Screening in Kazakhstan”, Kazakh National Medical University named after S.D. Asfendiyarov, Almaty, Kazakhstan

H-index: 2, Scopus ID: 57284444900

Research Interests:

• Oncoplastic breast surgery
• Breast cancer screening
• Medical and organizational research
• Postoperative rehabilitation
• Group-based cancer prevention programs

Additional Information:

• Participation in international conferences and overseas internships
• Active participation in international and national conferences, preparation and publication of scientific articles on diagnosis, surgical and conservative treatment, oncoplastic procedures, and comprehensive rehabilitation of breast cancer patients, presenting practical research results and clinical experience of KazIOR
• Experience in mentoring and supervising residents in oncology and mammology
• Author of patent No. 31922 on medical-organizational foundations of breast cancer screening and burden reduction

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Nazgul Omarbayeva

Oncological Breast Surgeon, JSC “KazIOR”; PhD Candidate

Education:

2007–2011: Sechenov First Moscow State Medical University, General Medicine, Moscow, Russia

2011–2012: Residency in Oncology, Sechenov First Moscow State Medical University, Moscow, Russia

2012–2014: Residency in Oncology (including Pediatric Oncology), JSC “KazIOR”, Almaty, Kazakhstan

2018: Retraining in Chemotherapy and Hormone Therapy for Malignant Tumors, JSC “KazIOR”, Almaty, Kazakhstan

2019: Retraining in General Surgery, Almaty, Kazakhstan

2019: First Qualification Category, Specialty: Oncology (Chemotherapy, Adult Mammology), Almaty, Kazakhstan

Specialization and Advanced Training:

2015: National Institute Hospital (NIH), Singapor

2016: National Cancer Institute (NCI), Washington, USA

2023: Scientific Internship, Curie Institute, Genetic Laboratory, France

Work Experience: over 14 years of professional experience in oncology

H-index: 2; Scopus ID: 57221587589

Research Interests:

Oncoplastic breast surgery

Personalized medicine

Genetic predispositions to cancer

Chemotherapy and targeted therapy

Early cancer detection methods

Additional Information:

Participation in international conferences and overseas internships

Active in national and international conferences, contributing to scientific articles on diagnosis, surgical and conservative treatment, oncoplastic procedures, and comprehensive rehabilitation of breast cancer patients

Mentoring and supervising residents in oncology and mammology

Publications in Q1 journals, patents, and intellectual property on early cancer diagnostics

Member of ESMO (European Society for Medical Oncology) and ASCO (American Society of Clinical Oncology); EUBREAST ambassador since 2024

Awarded “Best Young Scientist of the CIS”, 2020

Teaching at the Department of Oncology, D. Asfendiyarov Kazakh National Medical University; involved in training interns and residents

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Қалдыбеков Дәурен Болатұлы

PhD Candidate

Education:

2013 — General Medicine, Bachelor’s degree. Asfendiyarov Kazakh National Medical University, Almaty.

2015 — Internship in General Surgery, Higher School of Medicine. Asfendiyarov Kazakh National Medical University, Almaty.

2019 — Residency in Obstetrics and Gynecology (Adult and Pediatric). Scientific Center of Obstetrics, Gynecology and Perinatology, Almaty.

2022–2025- PhD in Medicine, NPJSC Asfendiyarov KazNMU.

Advanced Training:

2019 — European Society of Gynaecological Oncology (ESGO), Regional Seminar on Ovarian Cancer, April 2019, Tbilisi, Georgia.

2020 — Hands-on training on the AND Performer HT (HIPEC) system, January 2020, Almaty, Republic of Kazakhstan.

2021 — Advanced training program “Endoscopic Surgery in Gynecologic Oncology,” N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Saint Petersburg, Russia.

2024 — Training program on Prevention and Control of Oncological Diseases, Affiliated Oncology Center of Xinjiang Medical University, People’s Republic of China.

2024 — International research and clinical fellowship in Oncogynecology and Advanced Gynecologic Surgery, ESGO-accredited training center, "Nairi" Medical Center, Yerevan, Armenia.

Work Experience: 9 years

Research Interests: endometrial cancer: new approaches to diagnosis and treatment, molecular profiling, recurrence risk stratification; ovarian cancer: primary and interval cytoreduction; cervical cancer; reconstructive pelvic surgery; oncofertility; hormone therapy

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Alima Satanova

PhD

Education:

• 2014 —General Medicine, Bachelor’s degree, Asfendiyarov Kazakh National Medical University.
• 2016 — Internship in Obstetrics and Gynecology, Higher School of Medicine, Asfendiyarov Kazakh National Medical University, Almaty.
• 2018 — Residency in Oncology, Kazakh Oncology Institute, Almaty.
• 2020–2023 —PhD in Medicine, Asfendiyarov KazNMU, Almaty.

Advanced Training:

• 2018 — Advanced training program “Endoscopic Surgery in Gynecologic Oncology,” N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Saint Petersburg, Russia.
• 2019 — “Operative Gynecologic Oncology,” Gustave Roussy Institute, Paris, France.
• 2019 — “Operative Gynecologic Oncology,” Bergonié Institute, Bordeaux, France.
• 2019 — European Society of Gynaecological Oncology (ESGO), Regional Seminar on Ovarian Cancer, April 2019, Tbilisi, Georgia.
• 2020 — Hands-on training on the AND Performer HT (HIPEC) system, January 2020, Almaty, Republic of Kazakhstan.

Work Experience: 9 years

Research Interests: cervical cancer: HPV vaccination, screening, treatment of precancerous lesions; endometrial cancer: new approaches to diagnosis and treatment, tumor molecular profiling, recurrence risk stratification; ovarian cancer: HIPEC, primary and interval cytoreduction; oncofertility; hormone therapy.

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Khusan Umurzakov

Urologist, Oncological Surgeon of the Highest Category, Head of the Oncological Urology Center, Master of Medicine, PhD

Education:

Semipalatinsk State Medical Academy, Faculty of General Medicine, 2008.

Internship at the Regional Oncology Dispensary of Semey, Emergency Medical Care Hospital , 2008–2009.
Specialization in Urology, Almaty State Institute for Advanced Medical Training, 2009.

Specialization in Oncology, Almaty State Institute for Advanced Medical Training, 2012.

Specialization in “Early Diagnosis and Treatment of Malignant Tumors” (Adults and Children), Kazakh Oncology Institute, Almaty, 2013.

Master’s Degree in Specialized Medicine, Semey Medical University, 2017–2018. Thesis: “Improvement of Radical Treatment for Patients with Prostate Cancer Using Endoscopic Surgery.” Qualification: Master of Medicine.

Work Experience: Over 16 years in oncological urological surgery.

Internships and Scientific Visits: USA, European countries, China; active participation and presentations at international conferences.

Scientific Activities: Publications in peer-reviewed journals, including Scopus-indexed journals, as well as leading national oncology journals.

Memberships: European Association of Urology (EAU), European Society for Medical Oncology (ESMO), American Society of Clinical Oncology (ASCO); founder of the Kazakhstan Association of Oncourologists.

Awards: Recognized with professional awards for contributions to the development of oncological urology and the training of young specialists.

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Tolkyn Sadıkova

Oncogynecologist, Highest Qualification Category

Associate Professor, Department of Oncology named after S.N. Nugmanov

 

Education:

1990–1996: S.D. Asfendiyarov Almaty State Medical Institute, Almaty, Kazakhstan

1996–1999: Clinical Residency, Department of Oncology, KazNMU named after S.D. Asfendiyarov, Almaty, Kazakhstan

Specialization and Advanced Training:

Advanced training in Oncology, course: “Dyshormonal dysplasias, benign breast diseases as risk factors for breast cancer and ways to reduce them,” Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University – 120 hours, 11.12–25.11.2021.

Advanced training: “Communication skills in the healthcare system,” NPJSC “ S.D. Asfendiyarov Kazakh National Medical University”– 120 hours, 11.12–25.12.2023.

Advanced training in Obstetrics and Gynecology (pediatric gynecology, functional diagnostics, ultrasound diagnostics by specialty, endoscopy by specialty), course: “Innovative technologies in obstetrics and gynecology,” Kazakh Medical University “KSPH” LLC – 150 hours, 27.05–12.06.2024.

IV International Scientific and Practical Conference: 22–23.11.2024, “Multidisciplinary Approach in Obstetric and Gynecological Care,” Almaty Medical University, Speaker Certificate – 22 academic hours, Astana.

XI Regional Conference KARM: “Current Issues in Reproductive Medicine,” International Conference, 19–20.04.2024, Turkestan, Kazakhstan – Certificate, 18 hours.

Conference “BEST OF ASCO officially Licensed,” 13–14 July 2023, Almaty, Kazakhstan – Certificate.

IX Congress of Oncologists and Radiologists of Kazakhstan, 26–27 October 2023, Astana – Certificate, 18 credit hours.

Training: “Master Trainer on Human Papillomavirus (HPV) Vaccination,” Astana, 11–15 March 2024.

Forum KazONCO: Oncological Urology. Oncogynecology – 14 academic hours, 21–22 August 2025, Almaty, AO “KazIOR.”

EEMEA HPV Forum, 27–28 June 2025, Tbilisi, Georgia – 16 hours.

By the decision of the Committee for Quality Assurance in Science and Higher Education of the Ministry of Science and Higher Education of the Republic of Kazakhstan, Order No. 426 dated 19.03.2025, the academic title of Associate Professor was conferred on Tolkyn Tajdinovna Sadikova.

Work Experience: 29 years

In 2007, successfully defended a PhD dissertation on: “Antiviral Therapy in Precancerous Conditions and Carcinoma in Situ of the Cervix.”

Published approximately 40 scientific articles, 2 textbooks titled “Oncogynecology”, and 1 methodological guideline “Early Diagnosis of Cervical Cancer.”

Additional Information:

Trainee Lecturer, Department of Oncology, Jan 2000 – Jan 2002, KazNMU, Almaty

Assistant, Jan 2003 – Jan 2014, KazNMU, Almaty

Deputy Head, Department of Oncology, Jan 2014 – Present, KazNMU, Almaty

Diagnostics and Treatment: Diagnosis and treatment (including all types of surgical interventions) of oncogynecological patients.

Head of Paid Services, Jan 2017 – Present, AO “KazIOR,” Almaty

Curator of the Gynecology Department, Jan 2017 – Present, AO “KazIOR,” Almaty

Independent Expert, Committee for Medical and Pharmaceutical Control, Ministry of Health, RK

Member of the Academic Council and Educational Programs Committee, School of General Medicine, KazNMU named after S.D. Asfendiyarov, Almaty

Member of the working group for developing professional standards in oncogynecology and the Oncology Committee, Educational and Methodological Association of the Republican Educational and Methodological Council

Reviewer for the specialized scientific journal “Oncology and Radiology of Kazakhstan,” KOKSON, Ministry of Education and Science, RK

Member of the European Society for Medical Oncology (ESMO)

Member of the European Society of Gynecological Oncology (ESGO)

Member of the International Gynecologic Cancer Society (IGCS)

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Tatiana Goncharova

Scientific Secretary, JSC “Kazakh Oncology Institute”

Academic Degree and Title: Doctor of Biological Sciences, Professor Academician of the International Public Academy of Environmental Safety and Environmental Management (Russian Federation)

Education

Kazakh State University named after S.M. Kirov (1980), Alma-Ata, Republic of Kazakhstan. Degree: Biologist, Teacher of Biology and Chemistry

Candidate of Biological Sciences, Specialty 14.00.14 – Oncology (1994)

Doctor of Biological Sciences, Specialty 14.00.14 – Oncology (2005)

Total work experience: 47 years. Scientific and scientific-pedagogical activity: 42 years

Dissertations

Candidate of Biological Sciences: Chronothermometry and Chronotherapy of Tumors, Specialty 14.00.14 – Oncology (1994)

Doctor of Biological Sciences: Chronostructure of Bioactive Points in Malignant Growth, Specialty 14.00.14 – Oncology (2005)

Publications

Total scientific publications: 236

Monographs: 3

Author’s certificates: 3

Patents and pre-patents: 11

Methodological guidelines: 7

Hirsch Index: 2. ORCID ID: 0000-0003-2524-8750

Research Interests: biology, chronobiology, experimental oncology, radiobiology, ecology

Participation in Scientific Projects:

Chief Researcher in the following projects (grant fundings and targeted funding program), 2017–present:

PCF No. 49019/PCF-MHSW: “New Molecular-Genetic Methods for Pre-symptomatic Diagnostics and Treatment of Significant Diseases” (2017–2019)

GF No. AP05131940: “Potential of T-Lymphocyte Marker Detection for Early Diagnosis and Prognosis of Lung and Breast Cancer” (2018–2020)

PCF No. BR11065390: “Development of Innovative Technologies for Early Diagnosis and Treatment of Malignant Diseases Considering Modern Genomic Approaches” (2021–2023)

PCF No. OR12165486: “National Program for the Implementation of Personalized and Preventive Medicine in the Republic of Kazakhstan” (2021–2023)

PCF: “Development of Anticancer Therapy through Induced Glucose-Dependent Cytotoxic Oxidative Stress” (2022–2023)

BR24992841: “Optimization of Targeted Therapy for Aggressive Cancers Using the D-VC Drug Developed in Kazakhstan” (2024–2026)

PCF BR24992933: “Development and Implementation of Diagnostic Models, Treatment Technologies and Rehabilitation for Oncology Patients” (2024–2026)

Participation in the development of preventive measures based on the assessment of cancer incidence and mortality in the population of Kentau:

“Comprehensive Assessment of the Environment and Public Health of the City of Kentau and Adjacent Settlements” (2018–2019)

“Comprehensive Assessment of the Environment and Public Health in the Cities of Zhezkazgan, Satpaev and Ulytau District with the Creation of an Ecological GIS System” (2022–2024)

Awards:

State Award of the Republic of Kazakhstan – Medal “For Distinguished Labor”

Badge of the Ministry of Health of the Republic of Kazakhstan “Excellence in Healthcare”

Medal of the Ministry of Health “Labor Veteran”

Order of Merit “For Dedicated Service”

Certificates of Honor from the Ministry of Health

Letters of Appreciation from the Kazakh Oncology Institute

Professional Memberships:

Member of the National Editorial Board of the journal “Oncology and Radiology of Kazakhstan”

Member of the Academic Council, JSC “Kazakh Oncology Institute”

Member of the Local Ethics Committee, JSC “Kazakh Oncology Institute”